SURE Cell Line Development™

Selexis offers comprehensive and rapid solutions for the development of stable, high yield mammalian cell lines used in recombinant protein manufacturing.

High performance and stable mammalian cell lines
Services Overview
Research Cell Bank in 14 Weeks from Transfection
Cell Line Development
Lead Identification Genome Characterization MAb Humanization Licensing

Based on the Selexis SUREtechnology Platform™ and world-class expertise, Selexis SURE Cell line development™ Services significantly reduces the time, effort, and costs associated with developing high-performance mammalian cell lines for therapeutic protein production (e.g. monoclonal antibodies, growth factors, enzymes).


The development of high-yield production cell lines begins with the cloning of target genes into the SUREtech Vectors™ containing Selexis Genetic Elements™ (SGEs). These target gene-containing vectors are transfected either into the Selexis SURE CHO-M Cell line™ or another fully documented cell line provided by the client using the SUREfection™ procedure. From the stable transfectant population, and using up to two limiting dilution steps, Selexis selects for high expressing populations with favorable growth characteristics. A secondary limiting dilution step (single cell dilution) can be carried out, if necessary, to generate more clonal populations with even higher protein expression levels, SUREclones™.


Clonal Cell Line in as little as 14 weeks
chromosome single integration site

Single site integration in the
host cell genome reduces the risk of endogenous gene disruption for unmatched stability and grams per liter productivities.

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+1 415 738 4813