Scientific Poster

Lorem ipsum dolor sit amet, consectetur adipiscing elit, sed do eiusmod tempor incididunt ut labore et dolore magna aliqua. Donec ac odio tempor orci dapibus ultrices in iaculis nunc. Vitae sapien pellentesque habitant morbi tristique senectus. 

1 min read

CHO Fed-Batch Strategies To Rapidly Increase mAb Titer By 100% Without Sacrificing Product Quality

November 17, 2022

In the field of therapeutic antibody production, diversification of fed-batch strategies is flourishing inresponse to the market demand. All manufacturing approaches tend to follow the generally accepted dogmaof increasing titer since it directly increases manufacturing output. While titer is...

Read More
Keywords: CHO Intensified fed-batch ambr15 2022
1 min read

Rapid assessment of Aggregation of Biologics in Different Matrices and from Upstream and Downstream Development Process Stages

July 20, 2022

Assessing and controlling aggregation of biologics is vital to ensure the safety and efficacy of a biopharmaceutical product. In addition, aggregation has been recognized as a major issue for modern therapeutic modalities such as bispecific antibodies and Fc fusion proteins. Therefore, checking for...

Read More
Keywords: research cell bank Recombinant protein production next-generation sequencing genomic analysis
1 min read

Whole Genome Sequencing to Survey Genetic Changes in Stable CHO Cell Lines

May 14, 2017

Chinese hamster ovary (CHO) cells represent the most frequently applied host cell system for industrial manufacturing of recombinant protein therapeutics. Generating and identifying high producing clones in a fast and efficient way such that they do not lose their expression capability over time...

Read More
Keywords: research cell bank CHO Chinese hamster ovary next-generation sequencing SUREscan recombinant protein whole genome sequencing single nucleotide polymorphisms chromosomal rearrangements
1 min read

SELEXIS SUREscan: De-risking Cell Bank Generation with Comprehensive Genomic Analysis

September 29, 2015

Recombinant therapeutic protein production processes must guarantee a sufficiently small variability in the product quality. To keep this variability low, it is critical to run the process in a totally reproducible way. This requires controlling all cultivation parameters. The use of new analyzers,...

Read More
Keywords: research cell bank Recombinant protein production next-generation sequencing genomic analysis
1 min read

CHO Cell Library for the Selection of Improved Recombinant Therapeutic Protein Production Clones

May 29, 2013

In an effort to improve product yield of mammalian cell lines, we have previously demonstrated that our proprietary DNA elements, Selexis Genetic Elements (SGEs), increase the transcription of a given transgene1, thus boosting the overall expression of a therapeutic protein drug in mammalian cells....

Read More
Keywords: Chinese hamster ovary genome CHO Cell protein production clones cellular bottlenecks CHO-Mplus Library transcriptome
1 min read

Engineering CHO Cell Lines for Enhanced Production of Recombinant Proteins

June 17, 2011

The development of new mammalian expression platforms represents an ongoing need for advancing biophar-maceuticals towards human clinical trials.

Read More