Special Report on Cell Biology
Well CHOsen?
Ever-more complicated biologics push technical boundaries
By Randall C Willis
“Increasingly, we see scientists addressing complicated and intractable diseases by developing complex protein therapeutics such as bi- and tri-specific proteins, DARPins, triabodies, novel scaffolds decorated with peptides, enzymes and growth factors,” says Igor Fisch, CEO of Selexis. “While this can be great news for patients, these complex molecules are often more challenging to manufacture, as most are non-natural proteins that need to be expressed at high enough levels to be commercially viable….