Advanced Gene Technologies

Selexis Genetic Elements are proprietary epigenetic DNA-based elements that boost protein expression by controlling the dynamic organization of chromatin around the recombinant gene integration sites. The SGEs facilitate opening of the chromatin and stabilization of the transgene integration, which in turn allows for higher and sustained expression of recombinant proteins, even with multi-gene integrations.

• Facilitated opening of chromatin
• Enhanced transcription
• Stabilization of transgene integration
• Sustained multigene expression

Selexis SUREtech Vectors are proprietary vectors that are designed around Selexis Genetic Elements to ensure stable integration of a transgene into the host chromosome, ease of DNA cloning of the target gene into the vector backbone, and efficiency of transfection across a wide range of mammalian cell lines.

• Ease of DNA cloning of the gene of interest into the vector backbone
• Efficient and stable integration of the gene of interest into the host chromosome

Selexis SUREfection Procedures have been optimized to ensure optimal transfection efficiencies. This procedure usually leads to > 80% of cells being transfected.